Canonical singularities of orders over surfaces

We classify the possible ramification data and etale local structure of orders over surfaces with canonical singularities.Comment: This contains major revisions, primarily to help introduce the reader to the minimal model program for orders on surface

dYdX: Liquidity Providers' Incentive Programme Review

Liquidity providers are currently incentivised to provide liquidity through the LP Incentives Programme on dYdX. Based on the various parameters - makerVolume, depths and spreads, they are rewarded accordingly based on their activities. Given the maturity of the BTC and ETH markets, alongside other altcoins which enjoy a consistent amount of liquidity, this paper aims to update the formula to encourage more active and efficient liquidity, improving the overall trading experience. In this research, I begin by providing a basic understanding of spread management, before introducing the methodology with the various metrics and conditions. This includes gathering orderbooks on a minute interval and reconstructing the depths based on historical trades to establish an upper bound. I end off by providing recommendations to update the maxSpread parameter and alternative mechanisms/solutions to improve the existing market structures

Computation of topside ionograms from N/h/ profiles

Computation of topside ionograms from electron concentration profile

Potential Risks Inherent in Robotic Process Automation

Robotic process automation (RPA) uses automation technologies to perform tasks typically performed by humans. Although such technology has been instrumental in expediting business operations and lowering costs, it has also created several risks that warrant scrutiny. When discussing the drawbacks of automation, many will point to the number of jobs lost to the influx of automation. However, there are technology risks that organizations must consider such as fraud and cybersecurity. Fraudsters may utilize RPA to commit more novel and subtle technological and cyber security fraud. Organizations may implement internal control measures to prevent or mitigate such schemes, segregation of duties, and change management. RPA has many benefits, but the effective use of such technology will ultimately come down to how businesses adapt to risks in such an ever-changing business environment

Specification and Animation of Reactive Systems

SOLVE (Specification using an Object-based, LOTOS-defined, Visual language) is designed to allow formal requirements capture, particularly for reactive systems. The SOLVE language is object-based, and formally defined using LOTOS (Language Of Temporal Ordering Specification). SOLVE is supported by tools that allow direct visual animation of systems specified in this language. Animation is supported by translating a SOLVE specification automatically into a LOTOS specification, and then graphically simulating this. A further application is embodied in the XDILL tool that supports requirements specification and visual animation of digital logic circuits. Several illustrative SOLVE examples are given

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

Toll-like receptor (TLR) signaling induces a rapid reorganization of the actin cytoskeleton in cultured mouse dendritic cells (DC), leading to enhanced antigen endocytosis and a concomitant loss of filamentous actin–rich podosomes. We show that as podosomes are lost, TLR signaling induces prominent focal contacts and a transient reduction in DC migratory capacity in vitro. We further show that podosomes in mouse DC are foci of pronounced gelatinase activity, dependent on the enzyme membrane type I matrix metalloprotease (MT1-MMP), and that DC transiently lose the ability to degrade the extracellular matrix after TLR signaling. Surprisingly, MMP inhibitors block TLR signaling–induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled. Podosome disassembly caused by TLR signaling occurs normally in DC lacking MT1-MMP, and instead requires the tumor necrosis factor α–converting enzyme ADAM17 (a disintegrin and metalloprotease 17), which demonstrates a novel role for this “sheddase” in regulating an actin-based structure

The normal ranges of cardiovascular parameters measured using the ultrasonic cardiac output monitor

The ultrasonic cardiac output monitor (USCOM) is a noninvasive transcutaneous continuous wave Doppler method for assessing hemodynamics. There are no published reference ranges for normal values in adults (aged 18– 60 years) for this device. This study aimed to (1) measure cardiovascular indices using USCOM in healthy adults aged 18–60 years; (2) combine these data with those for healthy children (aged 0–12), adolescents (aged 12–18), and the elderly (aged over 60) from our previously published studies in order to present normal ranges for all ages, and (3) establish normal ranges of USCOM-derived variables according to both weight and age. This was a population- based cross-sectional observational study of healthy Chinese subjects aged 0.5–89 years in Hong Kong. USCOM scans were performed on all subjects, to produce measurements including stroke volume, cardiac output, and systemic vascular resistance. Data from previously published studies (children, adolescents, and the elderly) were included. Normal ranges were defined as lying between the 2.5th and 97.5th percentiles. A total of 2218 subjects were studied (mean age = 16.4, range = 0.5–89; 52% male). From previous studies, 1197 children (aged 0–12, 55% male), 590 adolescents (aged 12–18, 49% male), and 77 elderly (aged 60–89, 55% male) were included. New data were collected from 354 adults aged 18–60 (47% male). Normal ranges are presented according to age and weight. We present comprehensive normal ranges for hemodynamic parameters obtained with USCOM in healthy subjects of all ages from infancy to the elderly

Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer

© 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. Funded by Friends of ANCHOR NHS Grampian Endowment Fund. Grant Number: 12/50Peer reviewedPublisher PD